Among patients with resistant PV and JAK2 mutation included in the RESPONSE-1 trial [181], the rate of grade 3 or 4 infections at week 32 was 3.6% and 2.7%, respectively, similar in both ruxolitinib-treated patients and the control group treated with the best available therapy; VZV infections, all of grade 1 or 2, occurred in seven patients in the ruxolitinib group (6.4%) as compared with no patients receiving standard therapy. The gene discussed is JAK2; the disease is infection.