ITLN1 and infectious disease: Also, in line with previous reports suggesting that other infectious diseases up-regulate ITLN expression, a significant induction of itln3 expression (8.4-fold at 7hpi; 11.8-fold at 18hpi; 5.5-fold at 24hpi; 4.4-fold at 48hpi, P = 0.002 in all comparisons) was observed in Streptococcus pneumoniae (T4 serotype) infected (296 CFU; SD 32 CFU) embryos (Supplementary Figure 1).