We have previously reported that high-dose progesterone inhibits PI3K/Akt/mTOR signaling in GBM in vivo8, and our current data also show an inhibitory effect of progesterone on FoxO1, phospho-FoxO1, Glut1, GAPDH and PI3K/Akt/mTOR expression in GBM cells. The gene discussed is SLC2A1; the disease is glioblastoma.