This indicates that a USP19 mediated degradation of EWS-FLI1 supports the loss of Ewing sarcoma cell growth any time between 4 and 8 days (Supplementary Fig. 3c–e) where again expression levels of some, but not all of the tested target genes were modulated (Supplementary Fig. 3f). This evidence concerns the gene FLI1 and Ewing sarcoma.