This indicates that a USP19 mediated degradation of EWS-FLI1 supports the loss of Ewing sarcoma cell growth any time between 4 and 8 days (Supplementary Fig. 3c–e) where again expression levels of some, but not all of the tested target genes were modulated (Supplementary Fig. 3f). Here, EWSR1 is linked to Ewing sarcoma.