Hence, to determine whether CREB1 regulates the expression of factors responsible for pancreatic cancer cell migration, we searched for CREB1-binding sequences using the MatInspector tool (Genomatix)38, which identifies transcription-factor-binding sites in nucleotide sequences using a large library of weight matrices (Matrix Family Library version 11.0). Here, CREB1 is linked to familial pancreatic carcinoma.