In both populations, sST2 aids the risk stratification.5 6 In patients with acute HF, sST2 levels rose in the period prior to readmission for HF or death and serial sST2 measurements better predicted adverse outcomes compared with a single measurement, independent of serial NT-proBNP measurements.14 Finally, another study showed that higher levels of sST2 were predictive of survival after transcathether aortic valve implantation in patients with aortic stenosis.15 This evidence concerns the gene NPPB and hydrops fetalis.