Genome wide association study (GWAS) and other biomedical research found many candidate susceptibility genes for COPD, including but not limited to SERPINA1, EPHX1, GST, MMP12, TGFB1, SERPINE2, CHRNA3/5 and HHIP [12–15]. The gene discussed is CHRNA3; the disease is chronic obstructive pulmonary disease.