This variant recapitulates the genotype of many patients with hypertrophic cardiomyopathy (HCM).29,30 After differentiation into hiPSC-CMs, MyBPC (myosin-binding protein C) protein levels were reduced by 44% (P=0.01) of normal (Figure 6C and 6D), demonstrating haploinsufficiency. Here, MYBPC3 is linked to hypertrophic cardiomyopathy.