Among the selected candidates, AGR2, LAMC2, TAGLN2, MSLN, SERPINB5, CLDN18, EZR, FXYD3, GPRC5A, ITGA2, MST1R, NQO1, and SLC2A1 were upregulated in pancreatic neoplasms compared to normal tissue, while CDH3, EPHA2, GPRC5A, and SLC2A1 were upregulated in PC compared to pancreatic neoplasms, providing clues that they may be involved in PC initiation and development. This evidence concerns the gene GPRC5A and pachyonychia congenita.