SPDL1 and preeclampsia: The median concentration of serum sPD-L1 in 3rd-trimester healthy pregnant women was 4.575 (range 1.668–71.136) pg/mL, significantly not different than in women with early-onset preeclampsia, which was 2.119 (range 0.217–9.759) pg/mL (Figure 5).