Excessive intake of alcohol or fatty food can induce alcoholic or nonalcoholic fatty liver diseases (NAFLD) [3] by promoting de novo fatty acid synthesis through downregulation of AMP-activated protein kinase (AMPK), an important hepatic transcriptional regulator, and then its downstream acetyl CoA carboxylase (ACC) [4,5]. This evidence concerns the gene ACACA and metabolic dysfunction-associated steatotic liver disease.