MID1IP1 and acute myeloid leukemia: As shown in Figure 5a, overexpression of MID1IP1-reduced phosphorylation of AMPK by shikimic acid (80 μM) in AML-12 cells (Figure 5b), whereas depletion of MID1IP1 activated phosphorylation of AMPK/ACC in HepG2 cells (Figure 5c).