TGFB1 and neoplasm: Although it is still not understood how TGF-β signaling can be a tumor promoter during early stages of hepatic tumorigenesis, considering its pro-apoptotic and anti-proliferative functions, recent studies suggest that Snail, an EMT inducer and a TGF-β target, can play a pro-tumorigenic role in the liver [131,132,133] likely via promoting cellular proliferation.