APOE and hydrops fetalis: In addition, the putative mechanism of this paradoxical result may be correlated to several mediators contributing to the results of TG accumulation in the liver and the decrease of plasma TG, including the downregulation of microsomal angiopoietin-like 4 (an inhibitor of plasma lipoprotein lipase), triglyceride transfer protein (a hepatic TG transporter), and apolipoprotein E (a hepatic VLDL-TG secretion enhancer) under the HF-diet-fed condition, which is consistent with our previous studies [18,22] and other studies [21,23,24].