Supplementation of RMD to HF-diet-fed rats can (1) inhibit liver lipid-synthesis-related enzymes ACC and FAS activity and cholesterol-synthesis-related enzyme HMGCR activity, which reduces the liver TC and TG levels; (2) activate AMPK phosphorylation and upregulate CPT1-α protein expression, which increases the fatty acid β-oxidation in the liver; (3) activate AMPK phosphorylation and downregulate PPAR-γ protein expression, which reduces liver lipid accumulation. This evidence concerns the gene FAS and hydrops fetalis.