Strikingly, experiments using monocyte-derived immature human dendritic cells (MDDCs), which lack expression of Axl and Tyro3, demonstrated that upregulated expression of DC-SIGN correlates with enhanced virus attachment and productive infection, and that highly mannosylated glycans exposed on LASV GP1 surface interact with DC-SIGN during attachment [71]. The gene discussed is CD209; the disease is infection.