However, in contrast to this IFN-I promoting capacity of DDX3, mechanistic analysis has provided evidence that, in the case of LCMV, DDX3 suppresses the IFN-I response at late times of infection, still it remains to be confirmed whether this IFN-I-suppressive role of DDX3 is sustained in the context of an infection with the pathogenic LASV [89]. This evidence concerns the gene DDX3X and infection.