EV derived from hypoxic GBM cells are enriched in mRNA from HIF-1α target genes, including Bcl-2 interacting protein 3 (BNIP3), adrenamedullin (ADM), lysyl oxidase (LOX), N-myc downstream regulated 1 (NDRG1), procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) and serpin family E member 1 (SERPINE1) [62]. Here, PLOD2 is linked to glioblastoma.