It is plausible to suggest that overexpression of the components of the Wnt1/β-catenin dependent pathway by MH is due to heart failure and ischemic areas in the embryo heart during the wound healing process following acute MI, whereas MH-induced increased DKK-1 gene expression is mediated via platelet-induced endothelial activation. The gene discussed is DKK1; the disease is myocardial infarction.