For example, the selective ETA receptor antagonist S-0139 reduced BBB permeability, brain edema formation and infarct size after cerebral ischemia/reperfusion in rats [83], while Kim et al. [84,85] reported that the selective ETB receptor antagonist BQ788 blocked BBB disruption via inhibition of MMP-9 activation and ZO-1 protein degradation in experimental status epilepticus animals. Here, MMP9 is linked to brain ischemia.