The accentuated patterns of IHC staining for CK5/6 and CK20 observed in group 2 were reminiscent of the immunoprofiles that were associated with low-risk phenotypes of superficial papillary urothelial neoplasms which maintained stratified CK5/6 and CK20 expression of the normal urothelium [20,55]. Here, KRT5 is linked to papillary urothelial neoplasm.