SHC1 and cancer: Of note, group 3 showed downregulation of several genes involved in major cell adhesion complexes, including adherens junction (CDH8, CLCA2) [35,36,37], desmosome (SPINK5) [38], focal adhesion (MYO10, SHC1) [39,40], and basement membrane and the interaction with it (LGALS8, LAMA2, COL7A1, ITGB4) [41,42], with tight junction (CLDN4) being the exception [43], which would promote migration and invasion of cancer cells.