Interestingly, subgroups of non-muscle-invasive UTUC classified by CK5/6 and CK20 immunoprofiles showed contradicting prognoses to those of MIBC: CK5/6-low/CK20-high early UTUC had the worst outcome [19,20]. The gene discussed is KRT5; the disease is renal pelvis/ureter urothelial carcinoma.