Sulphonated nanocellulose obtained from Khaya sengalensis seed showed renal toxicity in rats, manifested by hypernatremia, enhancement of the antioxidant status and immunohistochemical expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the kidneys [70]. Here, PTGS2 is linked to Hypernatremia.