Sulphonated nanocellulose obtained from Khaya sengalensis seed showed renal toxicity in rats, manifested by hypernatremia, enhancement of the antioxidant status and immunohistochemical expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the kidneys [70]. This evidence concerns the gene NOS2 and Hypernatremia.