Similarly, muscle contraction has been shown to recruit muscle microvasculature and increase muscle uptake of insulin during a systemic lipid infusion [43,44] and adiponectin, which induces microvascular recruitment via 5’ adenosine monophosphate-activated protein kinase (AMPK) activation and NO production, ameliorates metabolic insulin resistance in rats fed a HFD [53,54]. This evidence concerns the gene INS and Insulin resistance.