Indeed, in skeletal muscle, the delay in insulin-stimulated glucose disposal occurs before insulin receptor binding and is due to the time required for plasma insulin to gain access to the insterstitial compartment [60] and in people with obesity and T2DM, insulin-mediated glucose disposal and muscle glucose uptake are clearly delayed compared to lean individuals [61]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.