Next-generation sequencing has contributed to the discovery of novel FPC susceptibility genes such as PALB2 or ATM. Initially, Murphy et al. identified germline BRCA2 mutation in 5 of 29 (17.2%) FPC patients, including 3 cases harboring 6174delT frameshift variant [46]. This evidence concerns the gene PALB2 and Familial adenomatous polyposis.