According to a retrospective review of 36 metastatic PC patients receiving the leucovorin calcium, fluorouracil, irinotecan hydrochloride and oxaliplatin (FOLFIRINOX) regimen, cases harboring mutations in DNA damage repair (DDR) genes (BRCA1, BRCA2, PALB2, MSH2 and FANCF) had marginally longer OS than those without the mutations (median OS: 14 months vs. 5 months), and multivariate analysis showed a significant association between DDR gene mutation status and longer OS [80]. This evidence concerns the gene BRCA1 and pachyonychia congenita.