As a second susceptibility gene, Jones et al. discovered a PALB2 frameshift variant (c.172_175 delTTGT) in one FPC patient by examining whole-exome sequencing data, and identified PALB2 truncation mutation leading to a stop codon in 3 of 96 (3.1%) FPC cases, in comparison with no mutation in the control cohort of 1,084 [50]. Here, PALB2 is linked to Familial adenomatous polyposis.