CLOCK and irritable bowel syndrome: Some other works have also underlined the critical role played by the gut microbiota in the clock-nutrition interplay [37, 57], so that the disruption of the circadian physiology, due to sleep disturbances or shift-working, may result in gastrointestinal diseases, such as Irritable Bowel Syndrome (IBS), an increased risk of obesity, diabetes, cardiovascular disease, and cancer [36, 38, 40, 43, 44, 50].