For analysis of ORFV-induced effects on keratinocyte differentiation, the expression of the differentiation markers keratin 1 (K1) and keratin 10 (K10), the transcription of the late differentiation marker loricrin, as well as presence of keratin 14 (K14) found in proliferating basal keratinocytes [22–26], were determined after ORFV infection of OTC and human foreskin explants. This evidence concerns the gene LORICRIN and infection.