KLK3 and posterior cortical atrophy: The threshold of 4.0 ng/mL (commonly used with the Tandem-R, Hybritech test) has to be revised based on the findings of 15.2% PCa in men with PSA ≤ 4 ng/mL in a cohort of 2950 men (aged 62–91 years) by Thompson and co-workers [22].