Table 1 gives an overview of commercially available biomarker tests, using liquid biopsy for the detection of high-grade (≥GS 7) PCa and assisting the physician with identifying patients for prostate biopsy and those eligible for active surveillance (for detailed information and more specialized tests, see [30]). Table 1 also demonstrates that PSA cutoff values vary between studies. Age-adjusted use of PSA cutoff values could significantly improve the sensitivity of PSA testing [23]. The gene discussed is KLK3; the disease is posterior cortical atrophy.