KLK3 and posterior cortical atrophy: While age-adjusted PSA cutoffs for total serum PSA (tPSA) and complexed serum PSA (cPSA) were superior to a fixed cutoff in a cohort of 3597 men who underwent routine biopsy, they could not improve the PCa detection rate of approximately 39% within the range of 2.0 ng/mL–20.0 ng/mL [23].