Longitudinal PSA screening to determine PSA velocity has been initially described to distinguish PCa from BPH in men aged >60 years at an average rate of change (ng/mL per year) of ≥0.75 with 90% specificity compared to 60% single PSA value ≥4 ng/mL [32]. The gene discussed is KLK3; the disease is benign prostatic hyperplasia.