KLK3 and posterior cortical atrophy: Combined into a score (ExoDx Prostate IntelliScore urine exosome assay (Exosome Diagnostics, Inc., Waltham, MA, USA)) with standard of care parameters: prostate-specific antigen level, age, race, and family history [42], this score was able to predict high-risk PCa, defined as GS ≥ 7, with a sensitivity of 92%.