KLK3 and posterior cortical atrophy: In a recent study including 496 participants with PSA ≥ 3.0 ng/mL, the accuracy of predicting PCa GS ≥ 7 was AUC 0.738 in the standard model (PSA + age) and AUC 0.820 in the advanced model integrating 4KScore® Test (p < 0.001).