With respect to the significance of IL5‐dependent STAT5 activation for differentiation toward eosinophils in normal hematopoiesis, we speculate that multiple pathways other than STAT5, including STAT1, STAT3, MAPK, AKT, and NF‐κB, are critical participants for CEL development and progression. The gene discussed is AKT1; the disease is Chronic Eosinophilic Leukemia, Not Otherwise Specified.