LEP and cancer: In this study, two studies were inconsistent with HWE.24, 30 When we excluded these studies, we also found that LEP G19A polymorphism decreased the risk of overall cancer (A vs G: OR = 0.92, 95% CI = 0.87–0.97, P = 0.002; AA vs GG: OR = 0.87, 95% CI = 0.75–0.99, P = 0.041 and GA/AA vs GG: OR = 0.90, 95% CI = 0.83–0.96, P = 0.003).