In addition, we also found that the G19A polymorphism in LEP gene was correlated with a decreased susceptibility of CRC in homozygote comparison (OR = 0.80, 95% CI: 0.66‐0.97, P = 0.023) and recessive model (OR = 0.75, 95% CI: 0.63‐0.90, P = 0.002). This evidence concerns the gene LEP and colorectal carcinoma.