KEGG pathway analysis on cardiac loop genes reveals enrichments for terms, such as dilated cardiomyopathy, vasopressin-regulated water reabsorption, and hypertrophic cardiomyopathy (Figure 4B) (the genes within these terms include: Adcy6, Aqp3, Creb3l4, Des, Itgb5, Itga9, Myl2, Myl3, and Stx4a). This evidence concerns the gene DES and dilated cardiomyopathy.