For further investigation, the following issues should be addressed: (1) to explore the utility and feasibility of COL5A2 as a marker in clinical practice; (2) to verify the exact role of COL5A2 in cancer invasion, and elucidate whether it is a key player or just a bystander; (3) to further figure out in which pathways is COL5A2 really involved and to locate key mechanisms that may guide personalized treatment strategy. The gene discussed is COL5A2; the disease is cancer.