In addition, members of the Gadd45 family serve as key regulatory genes in DNA damage repair pathway with p53 as the central link, whereas the upregulation of Gadd45 plays an important role in the regulation of G2/M cell cycle checkpoints and the maintenance of genomic stability to inhibit the cell transformation and the malignant tumor progression (Wang et al., 1999). The gene discussed is TP53; the disease is cancer.