Single nucleotide polymorphisms around PIP4K2A are associated with ALL susceptibility through impacting expression level of PIP4K2A, and accumulating evidence indicates the potential role of PIP4K2A on cancer cells, however, it is poorly understood that how PIP4K2A impact on tumorigenesis (including leukemogenesis). Here, PIP4K2A is linked to acute lymphoblastic leukemia.