For instance, PIP4K2A expression is strongly impacted by the genotypes of its adjacent single nucleotide polymorphisms (SNPs), which have been validated in several independent patient cohorts for ALL susceptibility (Walsh et al., 2013; Liao et al., 2016), suggesting PIP4K2A SNPs may play role on leukemogenesis through inducing its overexpression. Here, PIP4K2A is linked to acute lymphoblastic leukemia.