Above findings reveal quite close interactions between PIP4K2A and TFDP1 as well as the important role of TFDP1 in regulatory network of PIP4K2A. However, no clear binding motif information is available due to the limited studies on TFDP1. Some other candidates are linked to PIP4K2A according to PPI prediction, and we considered it is appropriate to start with these leukemia-related or cancer-related genes in order to reveal the transcriptional regulatory network of PIP4K2A in B-ALL. The gene discussed is PIP4K2A; the disease is precursor B-cell acute lymphoblastic leukemia.