Meanwhile, SNPs in IKZF1 are also significantly associated with ALL susceptibility across multiple ethnicities, probably through impacting on the expression level of IKZF1. Therefore, the expression correlation of IKZF1 with PIP4K2A indicates that these two genes may interact with each other to facilitate leukemogenesis as well as tumorigenesis. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.