To sum up, we have utilized available public microarray datasets and developed a systematic screening to find expression-based regulatory network of PIP4K2A. Because very limited studies have reported to explore the functional role of PIP4K2A on leukemogenesis despite of its significant association with ALL susceptibility as well as overexpression in multiple types of cancers, our findings may shed a new light on epigenetic regulation of PIP4K2A, and provide a clue for the further functional studies on this gene in cancer. The gene discussed is PIP4K2A; the disease is cancer.