RPL5 and Diamond-Blackfan anemia: For instance, studies in Diamond-Blackfan anemia (DBA) demonstrated that mutations in 60S or 40S ribosomal proteins [such as RPL5, RPL11, RPS7, RPS10 among others (Tahmasebi et al., 2018a)] decrease the ribosome levels but leave the composition of the ribosomes intact.