FFAR2 and colitis: In addition, Kim et al. showed that mice lacking the G-protein coupled receptor GPR43, one of the main receptors for SCFAs in the intestine, exhibited higher susceptibility to pathogenic infections, DSS-induced colitis and Azoxymethane (AOM)/DSS-induced carcinogenesis, all associated with increased frequencies of colonic LP TH17 and decreased frequencies of Treg cells (112, 113).