Importantly, proteomic profiling identified FLNA and ACTG were uniquely changed in RoR values in ChD CA and ChD CS subjects, respectively (Figures 3C,D), and SNO ACTG (spot# 563) was also differentially expressed between CA and CS patients (Figure 3E), and appears to be a hallmark of ChD severity. The gene discussed is ACTG1; the disease is Cowden syndrome 1.