Note that proteomic profile identified some of the protein spots (e.g., PSMB3, SH3BGRL2, ACTB, THBS1) that were significantly changed in RoR values in both ChD CA and ChD CS patient groups; and other proteins (e.g., ACTG, ALB, HNRNPA1, PTH2R, KRT83, MPO, FGB, and ACTB) exhibited significant differences in RoR values between ChD CA and ChD CS subjects (Figure 3E). The gene discussed is THBS1; the disease is Cowden syndrome 1.