Eight of these molecules (732-THBS1, 697-BEST3, 808-PPBP, 866-S100A6, 424-TPM4, 704-SH3BGRL2, 582-KRT1, and 723-YY1) were significantly increased in SNO modification levels (indicated by negative RoR values) in ChD CA as well as ChD CS patients. The gene discussed is TPM4; the disease is Cowden syndrome 1.