Note that proteomic profile identified some of the protein spots (e.g., PSMB3, SH3BGRL2, ACTB, THBS1) that were significantly changed in RoR values in both ChD CA and ChD CS patient groups; and other proteins (e.g., ACTG, ALB, HNRNPA1, PTH2R, KRT83, MPO, FGB, and ACTB) exhibited significant differences in RoR values between ChD CA and ChD CS subjects (Figure 3E). This evidence concerns the gene SH3BGRL2 and Cowden syndrome 1.