Eight of these molecules (732-THBS1, 697-BEST3, 808-PPBP, 866-S100A6, 424-TPM4, 704-SH3BGRL2, 582-KRT1, and 723-YY1) were significantly increased in SNO modification levels (indicated by negative RoR values) in ChD CA as well as ChD CS patients. This evidence concerns the gene THBS1 and Cowden syndrome 1.