Downstream of cytosolic calcium overload, inhibition of the mitochondrial permeability transition pore (MPTP) by genetic deletion or pharmacological inhibition of peptidyl prolyl isomerase D (cyclophilin D, encoded by Ppif gene) prevents ATP loss and improves biochemical, immunological and histopathological parameters in non-AA models of AP (Shalbueva et al., 2013; Mukherjee et al., 2016). The gene discussed is PPID; the disease is alkaline phosphatase measurement.