SOD1 and amyotrophic lateral sclerosis: In one report, hepcidin plasma concentrations were measured in SOD1 transgenic rats (G93A) at 12 weeks (asymptomatic, ALS stage I), 21 weeks (disease onset, ALS stage II) and 24 weeks (end-stage disease, ALS stage III) of age, and were significantly increased in the blood of ALS II and III animals (Halon et al., 2014).