Diagnostic workup should also include screening for molecular mutations in genes such as NPM1, FLT3, CEPBA, RUNX1, ASXL1, DNMT3A, and TP53 and is especially important in AML with normal karyotype where these findings can define the subtype of the disease [1, 47–49]. The gene discussed is TP53; the disease is acute myeloid leukemia.