DNMT1 and esophageal cancer: We found that for 7 esophageal cancer cell lines PD0325901 treatment down-regulated both UHRF1 and DNMT1 at the level of proteins (Fig. 4d) and mRNAs (Fig. 4e) in all lines except KYSE510, a result that is essentially identical to that of 2i on UHRF1 and DNMT1 proteins (Fig. 2b) and mRNAs (Fig. 2c,d) in these cells.