Notably, 2i treatment also markedly down-regulated the levels of UHRF1 and DNMT1 proteins in all esophageal cancer cells (KYSE150, KYSE410, KYSE140, KYSE520, KYSE30, and KYSE450) with the only one exception of KYSE510, in which UHRF1 protein level was unchanged (Fig. 2b). This evidence concerns the gene UHRF1 and esophageal cancer.