Given our surprising results regarding Lgr5 expression in Notch1+ cells (Fig. 3b,c), we then compared the signature of Notch1+ tumour cells to the transcriptome of Lgr5+ tumour cells33 and found an inverse correlation by GSEA, suggesting major differences between these two tumour cell populations (Fig. 3g). This evidence concerns the gene LGR5 and neoplasm.