However, thanks to this comparative exploration, we could identify pathways specifically activated in the Notch1+ tumour population, such as TGF-beta, ErbB and Hippo signalling pathways, and others that result statistically different only in Lgr5hi adenoma cells, i.e. JAK/STAT, mTOR, Hedgehog signalling. This evidence concerns the gene NOTCH1 and neoplasm.