Since the effect of PI3K on intracellular calcium activates cell migration, PI3Kgamma is also believed to be the primary target for chemokine-induced neutrophil movement and chemotactic eosinophilia in several lung disorders, including chronic obstructive pulmonary disorder (COPD)16 and asthma17. The gene discussed is PIK3CG; the disease is chronic obstructive pulmonary disease.