The response of TBM patients at day 180 was higher than that of healthy controls for cytokines induced by multiple stimuli: IFN-γ and IL-1RA induced by BCG; TNF-α, IFN-γ, IL-6, IL1-RA induced by M. tuberculosis; TNF-α, IFN-γ and IL-1RA induced by S. pneumoniae; and IL-1RA induced by C. albicans (p < 0.05 for all, data not shown). The gene discussed is TNF; the disease is meningeal tuberculosis.