However, we observed a significant increase in IKZF1, IKZF3, and KPNA2 expression in patients with gains at chromosomes 5, 9 and 15, all of which exhibited gain (a borderline significant difference in IKZF3 expression was observed in MM patients with gain of chromosome 9, P = 0.057). This evidence concerns the gene IKZF3 and Miyoshi myopathy.