AGTR1 and hypertensive disorder: In the present experiments, we first test whether systemic administration of an AT1R antagonist that is commonly used to treat hypertension (losartan) can reverse the extinction consolidation deficit that is found in female rats with low levels of estradiol, first by OVX, and then by a less invasive and more translationally relevant pharmacological treatment with the hormonal contraceptive (HC), levonorgestrel.