Interestingly, overexpression of SMURF1/2 did not change TGFR1 levels under basal and TGF-β-stimulated conditions in scleroderma fibroblasts, while it reduced both basal and TGF-β stimulated levels of TGFR1 in normal skin fibroblasts. The gene discussed is SMURF1; the disease is scleroderma.