Compared to UUO kidneys47,48 and human renal fibrotic kidneys49, scleroderma fibroblasts obtained from the affected areas exhibited increased SMAD7 levels and TGFR1 stability, while there was no significant difference in SMURF2 levels compared with normal fibroblasts from healthy volunteers51. The gene discussed is SMURF2; the disease is scleroderma.