The expression of BECN1 changed conversely after overexpression of BCL2L10, which proved that the expression level of BCL2L10 was negatively correlated with that of BECN1. To determine whether there is a direct interaction between BCL2L10 and BECN1, we first detected the co-localization in HCC cells. The gene discussed is BECN1; the disease is hepatocellular carcinoma.