NR1D1 and rheumatoid arthritis: RORC was a member of a Th17-promoting TF–TF module including RORA, NR1D1, and VAX2 (Fig. 5C, light-blue square; Supplemental Figs. S14–S17); functional annotations for this cluster include “IL23 signaling” and “rheumatoid arthritis,” which are consistent with prior knowledge.