Although gangliosphingolipids are not known to play a role in MG they are critical in maintaining the integrity of the muscle endplate through their formation of lipid rafts which stabilize membrane bound receptors and signaling molecules such as AChR [29], GP130 (or IL6ST) [30], CD55 (DAF) and CD59 [31, 32]. This evidence concerns the gene CD59 and myasthenia gravis.