Specifically, the modification of E-cadherin protein at Asn-554 with β1,6-N-acetylglucosamin (β1,6GlcNAc)-branched N-glycan catalyzed by N-acetylglucosaminyltransferase V (GnT-V) disrupts its cell adhesion function and therefore enhances tumor invasion [51, 52]. The gene discussed is MGAT5; the disease is neoplasm.