ESR1 and breast neoplasm: The Western dietary pattern was significantly associated with an 18% increase in the risk of estrogen receptor (ER+) and/or progesterone (PR+) breast tumors (12 studies, RR 1.18, 95% CI 1.04, 1.33, P = 0.012; I2 = 59.2%, P = 0.005; Fig. 5A).