Kinase B (AKT)/extracellular signal-regulated kinase (ERK) signaling-related proteins which are usually elevated in cancer cells were also altered with LINGO2 suppression—an increase in phospho-Glycogen synthase kinase-3 (pGSK3β) and a decrease in total AKT, phospho-AKT (pAKT), phospho-ERK kinase (pMEK), total ERK, and phospho-ERK (pERK) was observed. Here, LINGO2 is linked to cancer.