AIRE and Neurodegeneration: Previous studies showed that FAC1 represses transcription of the APP gene to influence neuronal development and neuro-degenerative diseases in human [33], AIRE transcriptionally activates the IL-6 in androgen-independent cells to modulate the prostate tumor microenvironment in mice [34], and FAST1 directly regulates mesodermal gene expression to mediate the form of mesodermal in the Xenopus embryo [35].